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Studies on protein adsorption in a vortex flow reactor

Paper ID Volume ID Publish Year Pages File Format Full-Text
35895 45113 2007 10 PDF Available
Title
Studies on protein adsorption in a vortex flow reactor
Abstract

The performance of a vortex flow reactor (VFR) with suspended particles for protein adsorption was studied under varying operating conditions, and resin volume fractions. The VFR behaved as an expanded bed in the regimen of laminar vortices flow. Streamline DEAE was used for bovine serum albumin (BSA) adsorption. Expanded bed VFR experiments were performed with varying geometric aspect ratios (14.6, 28.6 and 40.0) and axial superficial velocity (100–300 cm h−1) to investigate their influence on productivity and dynamic capacity. The results are compared with literature data on an expanded bed column (EBC). Adsorption breakthrough curves were fitting to a simple two-parameter model.

Keywords
BSA, bovine serum albumin; DEAE, diethyl aminoethyl; EBC, expanded bed column; EB-VFR, expanded bed vortex flow reactor; VFR, vortex flow reactorProtein adsorption; Expanded bed; Protein purification; Heterogeneous reactor; Vortex flow reactor
First Page Preview
Studies on protein adsorption in a vortex flow reactor
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 42, Issue 12, December 2007, Pages 1592–1601
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering