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Tunable hydroxyapatite wettability: Effect on adhesion of biological molecules

Paper ID Volume ID Publish Year Pages File Format Full-Text
35928 45115 2006 6 PDF Available
Title
Tunable hydroxyapatite wettability: Effect on adhesion of biological molecules
Abstract

Surface wettability modifications of biocompatible materials and wettability patterning are attractive methods for directed biological cells immobilization for tissue engineering, drug delivery, gene transfer, etc. Hydroxyapatite is known as an implantable biomimetic material and a substrate for effective adhesion of biological cells of various origins. Here we report the use of a low-energy electron irradiation to achieve tunable wettability of the hydroxyapatite in a wide range of contact angles, from 10° to 100°, with accuracy of ±3°. The incident electrons generate electron/hole pairs resulting in significant variation of the surface potential of the hydroxyapatite semiconductor and give rise to pronounced wettability modification. Tailoring the gradually varied wettability state in the hydroxyapatite nanoceramics enabled the differential binding of biological materials with different surface properties, such as bovine serum albumin (BSA) and deoxyribonucleic acid (DNA).

Keywords
Surface modification; Wettability; Hydroxyapatite; Adhesion molecule
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 12, December 2006, Pages 2367–2372
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us