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Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin

Paper ID Volume ID Publish Year Pages File Format Full-Text
35943 45115 2006 4 PDF Available
Title
Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin
Abstract

Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge, isolated from Artemisia annua L. is effective against both drug resistant and cerebral malaria causing strains of Plasmodium falciparum. The relative low yields of artemisinin in plants are a serious limitation to the commercialization of the drug. An alternative approach by microbial bioconversion of arteannuin B to artemisinin was carried out by Microbacterium trichotecenolyticum isolated from soil. Crude enzyme extract from cell free extracts were capable of microbial bioconversion of arteannuin B, the immediate precursor of artemisinin, to artemisinin. Attempts have been made to partially purify the proteins involved in bioconversion by ion exchange chromatography. Detection of artemisinin was done by thin layer chromatography, and quantified by HPLC.

Keywords
Arteannuin B; Artemisinin; Microbial bioconversion; Antimalarial agent; Artemisia annua L.
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Microbacterium trichotecenolyticum enzyme mediated transformation of arteannuin B to artemisinin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 12, December 2006, Pages 2464–2467
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us