Selection of high rosmarinic acid producing Lavandula vera MM cell lines
Selection of stable Lavandula vera MM cell lines producing high amounts of rosmarinic acid (RA) was performed using m-F-d,l-phenylalanine and p-F-d,l-phenylalanine. As a result, two callus lines L. vera MF and L. vera PF were obtained, which produced 1.95 and 1.71 times more rosmarinic acid in comparison with the parent culture. After adaptation of the selected callus lines in liquid media the achieved yields of rosmarinic acid were 2808.4 mg L−1 (in L. vera MF cell suspension) and 2594.6 mg L−1 (in L. vera PF cell suspension).
Journal: Process Biochemistry - Volume 41, Issue 9, September 2006, Pages 2068–2071