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Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines

Paper ID Volume ID Publish Year Pages File Format Full-Text
36100 45120 2006 6 PDF Available
Title
Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines
Abstract

Antiproliferative activity of 18 fish protein hydrolysates was measured on 2 human breast cancer cell lines grown in vitro. Three blue whiting, three cod, three plaice and one salmon hydrolysates were identified as significant growth inhibitors on the two cancer cell lines. Preliminary analysis of hydrolysates composition evidenced they contained a complex mixture of free amino acids, peptides with various sizes ranging up to 7 kDa and in a lower proportion, lipids and sodium chloride. RP-HPLC fractionation of fish hydrolysates is currently undertaken to purify anticancer peptides, lipids or other bioactive trace compounds responsible for this antiproliferative activity.

Keywords
Ara-C, cytosine-beta-d-arabinofuranoside; DAD, diode array detector; FPH, fish protein hydrolysate; SEC, size exclusion chromatographyBreast cancer; Fish protein hydrolysate (FPH); Antiproliferative activity
First Page Preview
Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 5, May 2006, Pages 1217–1222
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering