fulltext.study @t Gmail

Lipase-catalyzed enantioselective esterification of racemic ibuprofen coupled with pervaporation

Paper ID Volume ID Publish Year Pages File Format Full-Text
36157 45123 2006 6 PDF Available
Title
Lipase-catalyzed enantioselective esterification of racemic ibuprofen coupled with pervaporation
Abstract

Enantioselective esterification of racemic ibuprofen catalyzed by Candida rugosa lipase in isooctane was coupled with pervaporation of water by-produced by the reaction. A cross-linked poly(vinyl alcohol) (PVA) membrane and commercially available perfluorinated membranes (Nafion® 117 and Nafion® NE 450) were tested for selective removal of water from the reaction mixture. Effects of the reaction temperature, the concentration and nature of alcohol on the reaction rate and enantioselectivity were investigated systematically with and without pervaporation. The PVA pervaporation membrane appeared to be more suitable for the enantioselective esterification of ibuprofen than the Nafion® membranes. The highest initial rate and enantiomeric ratio were obtained at an equimolar ratio of 1-octanol/1-decanol to racemic ibuprofen regardless of the application of pervaporation. Raising the reaction temperature from 30 to 60 °C increased the reaction rate, but decreased the enantiomeric ratio. However, in most cases, the concomitant pervaporation operation brought about the enhancement of the reaction rate and the enantiomeric ratio. This was thought to be due to the selective removal of excess water by pervaporation, leading to the reduction of undesirable effects on the enzymatic reaction by the excess water.

Keywords
Enantioselective esterification; Lipase; Pervaporation; Ibuprofen; Kinetic resolution; Organic solvent
First Page Preview
Lipase-catalyzed enantioselective esterification of racemic ibuprofen coupled with pervaporation
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 2, February 2006, Pages 264–269
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us