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Advances in biotechnological production of 1,3-propanediol

Paper ID Volume ID Publish Year Pages File Format Full-Text
3621 178 2012 13 PDF Available
Title
Advances in biotechnological production of 1,3-propanediol
Abstract

1,3-propanediol (1,3-PD) is a chemical compound with myriad applications particularly as a monomer for the production of polyesters, polyethers and polyurethanes. It is a raw material for the production of biodegradable plastics, films, solvents, adhesives, detergents, cosmetics and medicines. Various strategies have been employed for the microbial production of 1,3-PD which include several bioprocess cultivation techniques facilitated by natural and/or genetically engineered microbes. Though 1,3-PD is produced in nature by the bioconversion of glycerol its production directly from sugars like glucose has been also made possible by the development of recombinant strains. This review presents the “state of the art” in the biotechnological production technologies of 1,3-PD particularly with respect to bioprocess engineering methods. It also highlights the significance of mathematical model-based approach for designing various bioreactor operating strategies to facilitate the improvement in 1,3-PD production. Attempt has also been made to focus on the protocols used for downstream processing of 1,3-PD and the associated problems. Finally concluding remarks on the future outlook on biobased 1,3-PD to reduce the dependence on disappearing fossil fuels are presented.

► “State of the art” in the biological production of 1,3-PD, its separation & key strategic bottlenecks for research has been summarized. ► Bioprocess engineering aspects for 1,3-PD production have been highlighted. ► Key role of modelling & its use for 1,3-PD process optimization has been proposed.

Keywords
1,3-PD, 1,3-propanediol; 3-HPA, 3-hydroxypropanaldehyde; 2,3-BD, 2,3-butanediol; DHAP, dihydroxyacetone phosphate; D, dilution rateGlycerol; 1,3-propanediol; Bioprocess design; Modelling; Polytrimethylene terephthalate; Downstream processing
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 64, 15 May 2012, Pages 106–118
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us