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Kinetics of Agrobacterium tumefaciens ubiquinone-10 batch production

Paper ID Volume ID Publish Year Pages File Format Full-Text
36218 45124 2006 5 PDF Available
Title
Kinetics of Agrobacterium tumefaciens ubiquinone-10 batch production
Abstract

A kinetic model of ubiquinone-10 production by batch fermentation with Agrobacterium tumefaciens ATCC4452 was firstly studied. After observation of experimental data, a model based on the logistic equation of ATCC4452 growth, ubiquinone-10 accumulation combined non-growth-associated and growth-associated contributions, and consumption of sugar for biomass formation and the maintenance of biomass, was developed. The optimal set of parameters was estimated by fitting the model to experimental data. The results predicted by the model were in good agreement with the experimental observations. Based on estimated kinetic parameters and characteristics of product formation and substrate utilization, a strategy of fed-batch operation was adopted in order to obtain more ubiquinone-10 accumulation. The final production of ubiquinone-10 reached 71.5 mg l−1 in 96 h of incubation, corresponding to more 3.5 times than that of batch operation, in fed-batch fermentation using four stage feeding strategy.

Keywords
Agrobacterium tumfaciens; Batch fermentation; Kinetic model; Ubiquinone-10; Parameters estimation; Fed-batch
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 8, August 2006, Pages 1908–1912
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us