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Recovery and pre-purification of (+)-dihydromyricetin from Hovenia dulcis

Paper ID Volume ID Publish Year Pages File Format Full-Text
36375 45131 2006 4 PDF Available
Title
Recovery and pre-purification of (+)-dihydromyricetin from Hovenia dulcis
Abstract

A novel recovery and pre-purification method were developed for producing (+)-dihydromyricetin from Hovenia dulcis, giving high purity and yield. The simple, efficient procedure involved biomass extraction, liquid–liquid extraction, and synthetic adsorbent treatment, followed by low-pressure chromatography. The use of active clay treatment and silica gel low-pressure chromatography in the pre-purification process allowed the efficient separation of (+)-dihydromyricetin from interfering compounds and, compared with alternative processes, increased the yield and purity of crude (+)-dihydromyricetin for subsequent high-performance liquid chromatography (HPLC) purification. (+)-Dihydromyricetin of over 50.0% purity could be obtained simply with a 71.8% overall yield from biomass using this pre-purification method, while minimizing solvent usage, size, and complexity of the subsequent HPLC operations for (+)-dihydromyricetin purification.

Keywords
(+)-Dihydromyricetin; Active clay treatment; Silica gel low-pressure chromatography; Recovery; Pre-purification
First Page Preview
Recovery and pre-purification of (+)-dihydromyricetin from Hovenia dulcis
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 3, March 2006, Pages 567–570
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering