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Modelling of the alcohol dehydrogenase production in baker's yeast

Paper ID Volume ID Publish Year Pages File Format Full-Text
36469 45133 2005 11 PDF Available
Title
Modelling of the alcohol dehydrogenase production in baker's yeast
Abstract

A mathematical model was formulated to simulate cell growth and enzyme production during the aerobic and micro-aerobic culture of the yeast Saccharomyces cerevisiae. Model development was based on three simplified metabolic events in the yeast: glucose fermentation, glucose oxidation and ethanol oxidation. Cell growth was expressed as a composite of these metabolic events. Their contributions to the total specific growth rate depended on the activities of the pacemaker enzyme pools of the individual pathways. The effect of substrate concentrations on the specific growth rate was described by a Michaelis–Menten equation. It was assumed that enzyme formation is cell growth associated. The model successfully predicted the dynamics of cell growth, glucose consumption, ethanol metabolism and alcohol dehydrogenase (ADH) production. A good agreement between model simulations and experimental data was achieved. It was observed that ADH production depends on the available oxygen concentration in the medium. In general, the proposed model appears to be useful for the design, scale-up, control and optimization of alcohol dehydrogenase production.

Keywords
Baker's yeast; Enzyme production; Alcohol dehydrogenase; Modelling; Fermentation; Oxygen
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 8, July 2005, Pages 2781–2791
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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