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Steroid 17β-reduction by microorganisms—a review

Paper ID Volume ID Publish Year Pages File Format Full-Text
36526 45136 2005 10 PDF Available
Title
Steroid 17β-reduction by microorganisms—a review
Abstract

17β-Reduction is one of key and widespread reactions of microbial steroid metabolism. It accompanies various steroid transformations by microorganisms and plays a role in the regulation of reducing equivalent pool and detoxication of exogenic steroids. The ability of microorganisms to reduce C17-ketosteroids has been known for 60 years, but most progress in the biochemistry and biotechnology of the process has been recorded in the past two decades. The regulation of 17β-hydroxysteroid dehydrogenase activity is of importance for the selectivity of various steroid biotransformations. The potential application of microbial 17β-reduction and the reverse reaction – 17β-oxidation – in the pharmaceutical industry for the production of 17β-hydroxy and 17-oxosteroids is shown. Microbial side chain cleavage of sterols in combination with 17β-reduction represents the shortest way to obtain testosterone in a single biotechnological operation thus replacing multistep chemical and/or combined biotech-chemical syntheses. This review highlights progress in the understanding of the biochemical basis of 17β-reduction and the biotechnological applications of the process.

Keywords
AD, androst-4-ene-3,17-dione; ADD, androsta-1,4-diene-3,17-dione; 17β-OH SDH, 17β-hydroxysteroid dehydrogenaseSteroid; 17β-Reduction; 17β-Hydroxysteroid dehydrogenase; Microbial transformation; Testosterone; Androstenedione
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Steroid 17β-reduction by microorganisms—a review
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 7, June 2005, Pages 2253–2262
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us