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Candidaparapsilosis CCTCC M203011 and the optimization of fermentation medium for stereoinversion of (S)-1-phenyl-1,2-ethanediol

Paper ID Volume ID Publish Year Pages File Format Full-Text
36536 45136 2005 6 PDF Available
Title
Candidaparapsilosis CCTCC M203011 and the optimization of fermentation medium for stereoinversion of (S)-1-phenyl-1,2-ethanediol
Abstract

The stereoinversion abilities of 13 species of Candida parapsilosi generally were compared. Candida parapsilosis China Center for Type Culture Collection (CCTCC) M203011 was observed to be the most suitable strain for preparation of (S)-1-phenyl-1,2-ethanediol (PED) by stereoinversion reaction. Identified by initial screening method of Plackett–Burman, the important medium components were MgSO4, ZnSO4, and KH2PO4. Response surface methodology (RSM) was applied to optimize further the preparation of (S)-PED. The optimal value for concentration of MgSO4, ZnSO4 and KH2PO4 were 1.17 g/L, 0.10 g/L and 9.41 g/L, respectively. Using this statistical optimization method, the enantioselective conversion ratio increased from 75.2% to 96.0%, while the enantiomerically excess increased from 84.2% entiomeric excess (e.e.) to 96.7% e.e.

Keywords
1-Phenyl-1,2-ethanediol; Stereoinversion; Candida parapsilosis; Response surface methodology; Plackett–Burman design
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Candidaparapsilosis CCTCC M203011 and the optimization of fermentation medium for stereoinversion of (S)-1-phenyl-1,2-ethanediol
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 7, June 2005, Pages 2345–2350
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us