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Production of nigerloxin, an enzyme inhibitor and a free radical scavenger, by Aspergillus niger using solid state fermentation

Paper ID Volume ID Publish Year Pages File Format Full-Text
36558 45136 2005 6 PDF Available
Title
Production of nigerloxin, an enzyme inhibitor and a free radical scavenger, by Aspergillus niger using solid state fermentation
Abstract

The fermentation parameters of production of nigerloxin, an inhibitor of lipoxygenase, through solid state fermentation by Aspergillus niger CFR-W-105 and its recovery was studied. Inhibitor production was influenced by the nature of the solid substrate, moisture content, incubation temperature, carbon, nitrogen, lipid and mineral supplements. Nigerloxin production was the highest when wheat bran was supplemented with 5% (w/w) trisodium citrate. The maximum nigerloxin obtained was 5.06 mg/g of dry wheat bran. Extraction of the fermented wheat bran using ethyl acetate under acidic pH range of 4–5.5 under agitated conditions resulted in maximum inhibitor recovery. Optimum time and temperature of extraction were determined to be 90 min and 30 °C, respectively.

Keywords
Nigerloxin; Solid state fermentation; Optimization; Enzyme inhibitor; Antioxidant; Fungi
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Production of nigerloxin, an enzyme inhibitor and a free radical scavenger, by Aspergillus niger using solid state fermentation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 7, June 2005, Pages 2517–2522
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us