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Fed-batch fermentation for hyperproduction of polysaccharide and ergosterol by medicinal mushroom Agaricus brasiliensis

Paper ID Volume ID Publish Year Pages File Format Full-Text
36634 45138 2006 5 PDF Available
Title
Fed-batch fermentation for hyperproduction of polysaccharide and ergosterol by medicinal mushroom Agaricus brasiliensis
Abstract

A process for simultaneous efficient production of bioactive polysaccharide and ergosterol by fed-batch fermentation of medicinal mushroom Agaricus brasiliensis was developed. Effects of carbon source and initial sugar concentration on the production of extracellular polysaccharide (EPS) and ergosterol were studied at first. Sucrose was suitable for EPS production although the cells could not grow well. Glucose was beneficial for the cell growth and production of ergosterol. When the initial glucose concentration exceeded 40 g/l, the ergosterol accumulation was decreased slightly. A repeated fed-batch fermentation strategy with glucose as carbon source, which feeding of glucose was commenced to 15 g/l from 72 to 120 h at 24 h intervals when the total glucose concentration of the broth was below 15 g/l in 7 l stirred bioreactor, was developed successfully to increase simultaneously EPS and ergosterol production. The maximum EPS and ergosterol production were 1.67 ± 0.08 g/l and 2.50 ± 0.04 mg/100 mg DW on 144 h, respectively, which were 26.9% and 17.2% higher than those by batch fermentation in the same cultivation conditions. It was the first reported to product simultaneously EPS and ergosterol in agitated fermentation of A. brasiliensis.

Keywords
Agaricus braziliensis; Cell density; EPS; Ergosterol; Fed-batch fermentation; Medicinal mushroom
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Fed-batch fermentation for hyperproduction of polysaccharide and ergosterol by medicinal mushroom Agaricus brasiliensis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 41, Issue 4, April 2006, Pages 970–974
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us