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Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro

Paper ID Volume ID Publish Year Pages File Format Full-Text
36646 45139 2005 4 PDF Available
Title
Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro
Abstract

Ginseng saponins 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells in a fermenter show a protection effect on human umbilical cord vein endothelial cells (VEC-304) from H2O2-induced cell apoptosis. When 50 μg/ml 20(S)-ginsenoside Rg2 was present in the culture medium for 8 h, the H2O2-damaged VEC-304 cells acquired about 11-fold (p < 0.01) on the amount and about 2-fold (p < 0.05) increase in PA activity compared with those untreated cells. And the Rg2 has a strong ability in scavenging intracellular ROS induced by H2O2.

Keywords
20(S)-Ginsenoside Rg2; VEC-304; Plasmonigen activator (PA); Reactive oxygen species (ROS)
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Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 10, October 2005, Pages 3202–3205
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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