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Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium

Paper ID Volume ID Publish Year Pages File Format Full-Text
36669 45139 2005 6 PDF Available
Title
Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium
Abstract

Compression coating was demonstrated as a novel encapsulation method for improving cell survival when cells were exposed to an acidic medium. Sodium alginate, which can form gels after being hydrated, has been exploited as the prime coating material. Probiotic cell containing powders were first compressed into a pellet, which was then encapsulated with the coating material by further compression. Results indicated significant improvement in survival of encapsulated cells when exposed to acidic media of pH 1.2 and 2. The encapsulated cells showed 104–105-fold increment in cell survival when compared to free cells under the test conditions. The formation of a hydrogel barrier by the compacted sodium alginate layer has shown to retard the permeation of the acidic fluid into the cells. This contributed to the enhanced cell survival. In addition, it could be deduced from in vitro tests that the release of encapsulated cells in the human digestive tract could occur near the end of the ileum and beginning of the colon. The mechanism of cell release is primarily due to the erosion of the alginate gel layer.

Keywords
Compression coating; Encapsulation; Lactobacillus acidophilus; Probiotic; Sodium alginate; Acid protection
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Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 10, October 2005, Pages 3346–3351
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us