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Improvement of gibberellic acid production using a model based fed-batch cultivation of Gibberella fujikuroi

Paper ID Volume ID Publish Year Pages File Format Full-Text
36683 45142 2005 6 PDF Available
Title
Improvement of gibberellic acid production using a model based fed-batch cultivation of Gibberella fujikuroi
Abstract

The production of gibberellic acid (GA3) by submerged cultivation of Gibberella fujikuroi was carried out in a 3 l fermenter. Under optimum culture conditions, the batch culture exhibited a maximum biomass concentration of 12 g/l and GA3 production of 1 g/l in 170 h. An unstructured mathematical model was proposed to describe the batch kinetics of fermentation and the model parameters were determined using batch kinetic data. The model was extrapolated to computer simulation and design (offline on computer) of nutrient feeding strategies for fed-batch cultivation for production of high concentration and productivity of GA3. Using this model-based nutrient feeding strategy; a volumetric productivity of 0.0168 g/(l h) for GA3 was obtained, which was approximately 2.9 times higher than that obtained in conventional batch cultures.

Keywords
C/N, carbon to nitrogen ratio; GA3, gibberellic acid; SSWR, sum of squares of weighed residuesFermentation; Gibberellic acid; Gibberella fujikuroi; Fed-batch cultivation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 40, Issue 6, May 2005, Pages 2045–2050
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us