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Production of the antitumoral retamycin during continuous fermentations of Streptomyces olindensis

Paper ID Volume ID Publish Year Pages File Format Full-Text
36768 45146 2004 7 PDF Available
Title
Production of the antitumoral retamycin during continuous fermentations of Streptomyces olindensis
Abstract

Continuous fermentations were performed in order to correlate the production of retamycin, an anthracycline antibiotic produced by Streptomyces olindensis in submerged cultures, with the dilution rate. Maximum retamycin production was achieved at a dilution rate of 0.05 h−1 (D=μx=0.05 h−1), while higher dilution rates caused a decrease in antibiotic production, which ceased completely at a dilution rate of 0.30 h−1. Otherwise, biomass productivity was favoured by high dilution rates, achieving a maximum at D=0.25 h−1, whereas retamycin productivity reached a maximum at D=0.05 h−1. Dilution rate influenced morphology, which was assessed by image analysis. The percentage of clumps decreased with an increase in dilution rate, with a correspondent increase in pellet percentage.

Keywords
Streptomyces; Continuous process; Morphology; Antibiotic; Retamycin
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Production of the antitumoral retamycin during continuous fermentations of Streptomyces olindensis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 39, Issue 12, 29 October 2004, Pages 2249–2255
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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