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Proteobacteria: microbial signature of dysbiosis in gut microbiota

Paper ID Volume ID Publish Year Pages File Format Full-Text
36785 45266 2015 8 PDF Available
Title
Proteobacteria: microbial signature of dysbiosis in gut microbiota
Abstract

•Members of the phylum Proteobacteria have a low abundance in the gut of healthy humans.•We provide an overview of correlations between a bloom of Proteobacteria and a diseased state.•We explain driving mechanisms for the uncontrolled expansion of the Proteobacteria population.•Proteobacterial load is suggested as a potential diagnostic criterion for dysbiosis and disease.

Recent advances in sequencing techniques, applied to the study of microbial communities, have provided compelling evidence that the mammalian intestinal tract harbors a complex microbial community whose composition is a critical determinant of host health in the context of metabolism and inflammation. Given that an imbalanced gut microbiota often arises from a sustained increase in abundance of the phylum Proteobacteria, the natural human gut flora normally contains only a minor proportion of this phylum. Here, we review studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community. We also propose that an increased prevalence of Proteobacteria is a potential diagnostic signature of dysbiosis and risk of disease.

Keywords
microbiota; Proteobacteria; dysbiosis
First Page Preview
Proteobacteria: microbial signature of dysbiosis in gut microbiota
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 9, September 2015, Pages 496–503
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering