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Biomimetic particles as therapeutics

Paper ID Volume ID Publish Year Pages File Format Full-Text
36787 45266 2015 11 PDF Available
Title
Biomimetic particles as therapeutics
Abstract

•Engineering particle material, size, and shape enables enhanced biomimicry.•Particles with paracrine delivery of soluble mediators mimic secretory cells.•Artificial cell membranes mimic the surface chemistry of cells and viruses.•Particles can be coated with naturally derived cell membranes for cell mimicry.

In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.

Keywords
biomimetic; micro/nanoparticle; biomaterial; drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 9, September 2015, Pages 514–524
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us