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Genome Editing of Structural Variations: Modeling and Gene Correction

Paper ID Volume ID Publish Year Pages File Format Full-Text
36807 45268 2016 14 PDF Available
Title
Genome Editing of Structural Variations: Modeling and Gene Correction
Abstract

The analysis of chromosomal structural variations (SVs), such as inversions and translocations, was made possible by the completion of the human genome project and the development of genome-wide sequencing technologies. SVs contribute to genetic diversity and evolution, although some SVs can cause diseases such as hemophilia A in humans. Genome engineering technology using programmable nucleases (e.g., ZFNs, TALENs, and CRISPR/Cas9) has been rapidly developed, enabling precise and efficient genome editing for SV research. Here, we review advances in modeling and gene correction of SVs, focusing on inversion, translocation, and nucleotide repeat expansion.

TrendsSVs are found in healthy individuals and have a positive effect on genetic diversity. However, through development of genome-wide sequencing technologies, it has been revealed that SVs can be involved in some diseases.The development of engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 has led to breakthroughs in the studies of diseases with SVs in terms of understanding mechanisms, disease modeling, and gene correction.We discuss current advances and future strategies in modeling and gene correction of SVs using engineered nucleases.

Keywords
genome editing; gene correction; engineered nucleases; inversion; translocation; short nucleotide repeat
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 34, Issue 7, July 2016, Pages 548–561
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us