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Antibody Approaches To Treat Brain Diseases

Paper ID Volume ID Publish Year Pages File Format Full-Text
36826 45270 2016 13 PDF Available
Title
Antibody Approaches To Treat Brain Diseases
Abstract

Recombinant antibodies are an emerging class of therapeutics with substantial promise to treat central nervous system (CNS) diseases such as Alzheimer's, Parkinson's, stroke, and brain cancers. However, poor blood–brain barrier (BBB) permeability hinders the progress of antibody therapies for conditions in which the target is located in the brain. Nonetheless, antibodies can nowadays be engineered to enhance their therapeutic applications and translocation of the BBB using the natural portals of the brain. This paper reviews advances in the development and engineering of therapeutic BBB-crossing antibodies and their high potential for treatment of CNS disorders.

TrendsAntibodies have proven utility as therapeutics, being highly selective and effective drugs to treat many diseases.Development of antibodies to treat CNS diseases is limited by the BBB.Several therapeutic antibodies for neurological diseases have failed to show significant clinical benefits.Re-engineering can be used to customize antibodies to both recognize endogenous transport systems at the BBB and act as drugs in the brain.

Keywords
blood–brain barrier; central nervous system disorders; brain drug delivery; recombinant antibodies; bispecific antibodies; molecular Trojan horses (MTH)
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Antibody Approaches To Treat Brain Diseases
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 34, Issue 1, January 2016, Pages 36–48
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us