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Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
36863 45275 2016 12 PDF Available
Title
Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery
Abstract

The development of novel neuropharmaceuticals requires the evaluation of blood–brain barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the BBB among different species, with the most important differences involving the expression of P-glycoprotein (P-gp), multidrug resistance-associated proteins, transporters, and claudins. In addition, functional studies have shown that brain pharmacokinetics of P-glycoprotein substrates are different in humans and rodents. Therefore, human BBB models may be an important platform for initial drug screening before in vivo studies. This strategy might help to reduce costs in drug development and failures in clinical studies. We review the differences in the BBB among species, recent advances in the generation of human BBB models, and their applications in drug discovery and delivery.

TrendsSignificant BBB differences between species.Derivation of human BBB models from human pluripotent stem cells and adult stem/progenitor cells.Derivation of pathological BBB models from human induced pluripotent stem cells.BBB models are useful to study the permeability of drugs and nanoformulations.

Keywords
blood–brain barrier; neuropharmaceuticals; in vitro models; neurodegenerative diseases; stem cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 34, Issue 5, May 2016, Pages 382–393
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us