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Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

Paper ID Volume ID Publish Year Pages File Format Full-Text
36864 45275 2016 14 PDF Available
Title
Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair
Abstract

Research over the past decade on the cell–biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GelMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GelMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.

TrendsIn gelMA hydrogels, the inherent bioactivity of gelatin is combined with the tailorability of photo-crosslinking.3D-generated tissue analogs need to be geometrically natural mimics that are biofunctionally and mechanically stable.GelMA will accelerate the development of cell-laden biofabricated constructs and will have a pioneering role in their translation to clinically relevant applications.

Keywords
gelatin-methacryloyl; hydrogel; photo-crosslinking; tissue engineering; biofabrication; regenerative medicine
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Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 34, Issue 5, May 2016, Pages 394–407
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us