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A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
36871 45276 2013 12 PDF Available
Title
A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
Abstract

•Recombinant DNA technologies are leading the rapid expansion of bispecific antibody formats.•The therapeutic potential of bispecific antibodies is being realized through creative design.•Bispecific antibodies are potentially underutilized reagents for diagnostics.

Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands. The next generation of bsAbs is developing due to significant improvements in recombinant antibody technologies. This review focuses on recent advances with a particular focus on improvements in format and design that are contributing to the resurgence of bsAbs, and in particular, on innovative structures applicable to next generation point-of-care (POC) devices with applicability to low resource environments.

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A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 11, November 2013, Pages 621–632
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us