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Dissecting the assays to assess microbial tolerance to toxic chemicals in bioprocessing

Paper ID Volume ID Publish Year Pages File Format Full-Text
36873 45276 2013 11 PDF Available
Title
Dissecting the assays to assess microbial tolerance to toxic chemicals in bioprocessing
Abstract

•Tolerance to toxic chemicals is a limiting issue in industrial bioprocesses.•Industrial practice should guide tolerance assay design.•Many parameters affect tolerance assays.•High-throughput assays play a key role in tolerance engineering.

Microbial strains are increasingly used for the industrial production of chemicals and biofuels, but the toxicity of components in the feedstock and product streams limits process outputs. Selected or engineered microbes that thrive in the presence of toxic chemicals can be assessed using tolerance assays. Such assays must reasonably represent the conditions the cells will experience during the intended process and measure the appropriate physiological trait for the desired application. We review currently used tolerance assays, and examine the many parameters that affect assay outcomes. We identify and suggest the use of the best-suited assays for each industrial bioreactor operating condition, discuss next-generation assays, and propose a standardized approach for using assays to examine tolerance to toxic chemicals.

Keywords
biofuels; renewables; bioremediation; bioreactor; tolerance assays
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Dissecting the assays to assess microbial tolerance to toxic chemicals in bioprocessing
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 11, November 2013, Pages 643–653
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us