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DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

Paper ID Volume ID Publish Year Pages File Format Full-Text
36890 45279 2015 9 PDF Available
Title
DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices
Abstract

DNA molecules can be assembled into custom predesigned shapes via hybridization of sequence-complementary domains. The folded structures have high spatial addressability and a tremendous potential to serve as platforms and active components in a plethora of bionanotechnological applications. DNA is a truly programmable material, and its nanoscale engineering thus opens up numerous attractive possibilities to develop novel methods for therapeutics. The tailored molecular devices could be used in targeting cells and triggering the cellular actions in the biological environment. In this review we focus on the DNA-based assemblies – primarily DNA origami nanostructures – that could perform complex tasks in cells and serve as smart drug-delivery vehicles in, for example, cancer therapy, prodrug medication, and enzyme replacement therapy.

TrendsRapid evolution of structural DNA nanotechnology: from platonic DNA structures to functional DNA devices.Tailored DNA-based assemblies can be used as advanced drug-delivery vehicles in various therapeutic applications.DNA nanodevices can target cells and trigger single-molecule level reactions in biological environment.Functional DNA nanostructures can serve as versatile molecular machines and preprogrammed templates in cells.

Keywords
DNA nanotechnology; DNA origami; self-assembly; drug delivery; cell uptake; immunostimulation; enzymatic payloads; biosensing; biocomputing
First Page Preview
DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 10, October 2015, Pages 586–594
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering