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Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides

Paper ID Volume ID Publish Year Pages File Format Full-Text
36891 45279 2015 16 PDF Available
Title
Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides
Abstract

Halogenated organic compounds (organohalides) are globally prevalent, recalcitrant toxic, and carcinogenic environmental pollutants. Select microorganisms encode enzymes known as reductive dehalogenases (EC 1.97.1.8) that catalyze reductive dehalogenation reactions resulting in the generation of lesser-halogenated compounds that may be less toxic and more biodegradable. Recent breakthroughs in enzyme structure determination, elucidation of the mechanisms of reductive dehalogenation, and in heterologous expression of functional reductive dehalogenase enzymes have substantially increased our understanding of this fascinating class of enzymes. This knowledge has created opportunities for more versatile (in situ and ex situ) biologically-mediated organohalide destruction strategies.

TrendsReductive dehalogenases catalyze reactions for potential organohalide destruction, which is a pressing global environmental problem.Recent crystal studies have shed light on structure–function relationships of these enzymes. Structure–function relationship and homology modeling will play a pivotal role in the full characterization of these enzymes moving forward.A summary of characterized and identified reductive dehalogenases is reported in this review, revealing the diversity of substrates and preferred electron donors for microorganisms capable of reductive dehalogenation.Recombinant expression of functional dehalogenases is a new breakthrough in this field, overcoming the problems of slow growth and low biomass densities of ORB, which will facilitate a rapid increase in the understanding of the biology and application of these enzymes.

Keywords
reductive dehalogenase; organohalide respiration; bioremediation; Dehalobacter; Dehalococcoides
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Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 10, October 2015, Pages 595–610
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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