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Natural photoreceptors and their application to synthetic biology

Paper ID Volume ID Publish Year Pages File Format Full-Text
36906 45282 2015 12 PDF Available
Title
Natural photoreceptors and their application to synthetic biology
Abstract

•We need precision technologies for perturbing specific cellular signaling pathways.•New technologies have emerged that use light for perturbing cellular processes.•We describe the design principles of natural photoreceptors.•We review how these principles are applied to synthetic signaling systems.

The ability to perturb living systems is essential to understand how cells sense, integrate, and exchange information, to comprehend how pathologic changes in these processes relate to disease, and to provide insights into therapeutic points of intervention. Several molecular technologies based on natural photoreceptor systems have been pioneered that allow distinct cellular signaling pathways to be modulated with light in a temporally and spatially precise manner. In this review, we describe and discuss the underlying design principles of natural photoreceptors that have emerged as fundamental for the rational design and implementation of synthetic light-controlled signaling systems. Furthermore, we examine the unique challenges that synthetic protein technologies face when applied to the study of neural dynamics at the cellular and network level.

Keywords
optogenetics; synthetic biology; protein engineering; photoreceptor; signal transduction
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Natural photoreceptors and their application to synthetic biology
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 2, February 2015, Pages 80–91
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us