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Synthetic protein switches: design principles and applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
36908 45282 2015 10 PDF Available
Title
Synthetic protein switches: design principles and applications
Abstract

•Engineered protein switches are increasingly used in molecular diagnostics.•Engineered protein switches can be used to sense and actuate cellular functions.•Empirical design rules to construct tailor-engineered protein switches are emerging.•Future synthetic signaling circuits will see networks of engineered protein switches.

Protein switches are ubiquitous in biological signal transduction systems, enabling cells to sense and respond to a variety of molecular queues in a rapid, specific, and integrated fashion. Analogously, tailor-engineered protein switches with custom input and output functions have become invaluable research tools for reporting on distinct physiological states and actuating molecular functions in real time and in situ. Here, we analyze recent progress in constructing protein-based switches while assessing their potential in the assembly of defined signaling motifs. We anticipate such systems will ultimately pave the way towards a new generation of molecular diagnostics and facilitate the construction of artificial signaling systems that operate in parallel to the signaling machinery of a host cell for applications in synthetic biology.

Keywords
synthetic biology; protein switches; protein engineering; molecular diagnostics; signaling; biosensors
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 2, February 2015, Pages 101–110
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us