fulltext.study @t Gmail

Synthetic biology in cell-based cancer immunotherapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
36918 45284 2015 13 PDF Available
Title
Synthetic biology in cell-based cancer immunotherapy
Abstract

•Synthetic biology will play an important role in advancing adoptive T cell therapy.•Engineered receptors and genetic circuits can make cell-based therapies safer and more powerful.•Cellular engineering and genome editing can further improve the T cell as a chassis for therapy.

The adoptive transfer of genetically engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. This form of cellular immunotherapy presents a unique opportunity to incorporate advanced systems and synthetic biology approaches to create cancer therapeutics with novel functions. We first review the development of synthetic receptors, switches, and circuits to control the location, duration, and strength of T cell activity against tumors. In addition, we discuss the cellular engineering and genome editing of host cells (or the chassis) to improve the efficacy of cell-based cancer therapeutics, and to reduce the time and cost of manufacturing.

Keywords
synthetic biology; genetic circuits; chimeric antigen receptors; immunotherapy; cancer
First Page Preview
Synthetic biology in cell-based cancer immunotherapy
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 8, August 2015, Pages 449–461
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us