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Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
36932 45287 2014 6 PDF Available
Title
Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells
Abstract

•Vaccines and viral vectors produced in animal cells constitute a growing research field and market.•Virus–host interactions can unveil targets for cell culture optimization.•Medium design strategies could improve productivities up to 8-fold.•Genetic manipulation of the host cell resulted in up to 100-fold increase of viral yields.

The past decade witnessed the entry into the market of new virus-based biopharmaceuticals produced in animal cells such as oncolytic vectors, virus-like particle vaccines, and gene transfer vectors. Therefore, increased attention and investment to optimize cell culture processes towards enhanced manufacturing of these bioproducts is anticipated. Herein, we review key findings on virus–host interactions that have been explored in cell culture optimization. Approaches supporting improved productivity or quality of vector preparations are discussed, mainly focusing on medium design and genetic manipulation. This review provides an integrated outline for current and future efforts in exploring cellular targets for the optimization of cell culture manufacturing of virus-based biopharmaceuticals.

Keywords
biochemical pathways; virus–host interactions; viral vectors; vaccines; medium design; genetic manipulation
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 12, December 2014, Pages 602–607
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
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