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Green genes: bioinformatics and systems-biology innovations drive algal biotechnology

Paper ID Volume ID Publish Year Pages File Format Full-Text
36934 45287 2014 10 PDF Available
Title
Green genes: bioinformatics and systems-biology innovations drive algal biotechnology
Abstract

•Microalgae are potential hosts for industrial biosynthesis of valuable compounds.•Genome sequences of many microalgae are available, but annotation lags behind.•We propose an integrative approach to improve algal protein annotation.•Systems-biology modeling of microalgae is crucial to facilitate algal engineering.

Many species of microalgae produce hydrocarbons, polysaccharides, and other valuable products in significant amounts. However, large-scale production of algal products is not yet competitive against non-renewable alternatives from fossil fuel. Metabolic engineering approaches will help to improve productivity, but the exact metabolic pathways and the identities of the majority of the genes involved remain unknown. Recent advances in bioinformatics and systems-biology modeling coupled with increasing numbers of algal genome-sequencing projects are providing the means to address this. A multidisciplinary integration of methods will provide synergy for a systems-level understanding of microalgae, and thereby accelerate the improvement of industrially valuable strains. In this review we highlight recent advances and challenges to microalgal research and discuss future potential.

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Green genes: bioinformatics and systems-biology innovations drive algal biotechnology
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 12, December 2014, Pages 617–626
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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