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High-throughput screening for integrative biomaterials design: exploring advances and new trends

Paper ID Volume ID Publish Year Pages File Format Full-Text
36935 45287 2014 10 PDF Available
Title
High-throughput screening for integrative biomaterials design: exploring advances and new trends
Abstract

•Advances in high-throughput methods for biomaterials development.•Discussion of upgrades in the field for the adaptation of array-based chips for tissue engineering.•New factors that must be taken into consideration in the development of more optimized chips.

With the increasing need for biomaterials and tissue engineering alternatives, more accurate, rapid, and cost-saving methods and models to study biomaterial–cell interactions must be developed. We review the evolution of microarray platforms used for such studies in order to meet the criteria of complex tissue engineering biological environments. Particular aspects regarding biomaterials processing, data acquisition, and treatment are addressed. Apart from in vitro array-based strategies, we also address emerging in vivo high-throughput approaches and their associated trends, such as the role of inflammation in regeneration. The up-scaling of high-throughput methods using single cell encapsulation systems is also explored. Possible limitations related to the use of such methods, such as spot-to-spot crosstalk, are also discussed.

Keywords
high-throughput; combinatorial; biomaterials; lab-on-chip testing; arrays
First Page Preview
High-throughput screening for integrative biomaterials design: exploring advances and new trends
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 12, December 2014, Pages 627–636
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering