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Exploiting cell surface thiols to enhance cellular uptake

Paper ID Volume ID Publish Year Pages File Format Full-Text
36948 45290 2012 6 PDF Available
Title
Exploiting cell surface thiols to enhance cellular uptake
Abstract

Efficient cellular delivery is one of the key issues that has hampered the therapeutic development of novel synthetic biomolecules such as oligonucleotides, peptides and nanoparticles. The highly specialized cellular plasma membrane specifically internalizes compounds through tightly regulated mechanisms. It is possible to exploit these natural mechanisms of cellular uptake with rationally designed reagents. Here, we discuss how thiol groups (-SH) naturally present on the cell surface (exofacial thiols) can be used to enhance cellular association and internalization of various materials bearing thiol-reactive groups in their structure. We propose that such thiol modifications should be considered in future design of synthetic biomolecules for optimized cellular delivery.

Keywords
cellular delivery; disulfide; peptide; cysteine; oligonucleotide; thiol
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 4, April 2012, Pages 185–190
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us