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A dynamic perspective of RNAi library development

Paper ID Volume ID Publish Year Pages File Format Full-Text
36951 45290 2012 10 PDF Available
Title
A dynamic perspective of RNAi library development
Abstract

Shortly after the dissertation of the mechanism of RNA interference (RNAi), various RNAi libraries for invertebrates, plants or mammals that enable loss-of-function genetic screens on a genome-wide scale have been developed. Joint academic and industrial effort has led to the commercial launch of many of these libraries and this field is expected to continuously evolve at incredible speed. This article comparatively reviews the principles and applications of different RNAi libraries: from earlier synthetic to recent lentiviral RNAi libraries. The unique properties and limitations of each library will be important references for instigators to choose a particular library for their specific application.

Keywords
RNAi library; genome-wide screen; invertebrates; plants; mammals
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A dynamic perspective of RNAi library development
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 4, April 2012, Pages 206–215
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us