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Physical analysis of virus particles using electrospray differential mobility analysis

Paper ID Volume ID Publish Year Pages File Format Full-Text
36952 45290 2012 9 PDF Available
Title
Physical analysis of virus particles using electrospray differential mobility analysis
Abstract

This review critically examines an emerging tool to measure viral clearance from biomanufacturing streams, monitor assembly of viruses and virus-like particles, rapidly identify viruses from biological milieu, assay virus neutralization, and prepare bionanoconjugates for bacterial detection. Electrospray differential mobility analysis (ES-DMA) is a tool of choice to simultaneously determine viral size and concentration because it provides full multimodal size distributions with subnanometer precision from individual capsid proteins to intact viral particles. The review contrasts ES-DMA to similar tools and highlights expected growth areas including at-line process sensing as a process analytical technology (PAT), bioseparating as a distinct unit operation, monitoring viral reactions, and interrogating virus–host protein interactions.

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Physical analysis of virus particles using electrospray differential mobility analysis
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 4, April 2012, Pages 216–224
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us