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Non-immunoglobulin scaffolds: a focus on their targets

Paper ID Volume ID Publish Year Pages File Format Full-Text
36963 45291 2015 11 PDF Available
Title
Non-immunoglobulin scaffolds: a focus on their targets
Abstract

•Non-immunoglobulin (non-Ig) scaffolds are small antibody alternatives.•139 binders of 20 different non-Ig scaffold types have been developed against 102 different targets.•Their main application is in the treatment and diagnosis of cancer and inflammatory diseases.•They can also be used in structural studies and post-translational modification monitoring.

Non-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, small single-domain proteins that require no post-translational modification, often lack disulfide bonds, and can undergo straightforward multimerization. Among the 20 different types of non-Ig scaffolds, Adhirons, Alphabodies, Centyrins, Pronectins, Repebodies, Affimers, and Obodies have been introduced in the past 4 years. 102 proteins have been specifically targeted by 139 different non-Ig scaffold binders. The most frequent application of non-Ig scaffolds is in the treatment and diagnosis of cancer and inflammatory diseases, and 10 non-Ig scaffolds have already been tested in clinical trials. Recently, non-Ig scaffolds have often been used in research as structure determination chaperones, for intracellular monitoring of post-translational modifications, and as antibody alternatives for microscopy, flow cytometry, and Western blotting.

Keywords
non-immunoglobulin scaffolds; antibody alternatives; binders
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 7, July 2015, Pages 408–418
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
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