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Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
36964 45291 2015 10 PDF Available
Title
Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering
Abstract

•Plants use modular pathways to produce thousands of diterpene natural products.•Diterpenes are used as in pharmaceutical, fragrance, food, and chemical industries.•Diterpene synthases are key to producing the diversity of diterpene scaffolds.•Enzyme discovery in plants provides new tools for diterpene metabolic engineering.

Plants produce thousands of diterpenoid natural products; some of which are of significant industrial value as biobased pharmaceuticals (taxol), fragrances (sclareol), food additives (steviosides), and commodity chemicals (diterpene resin acids). In nature, diterpene synthase (diTPS) enzymes are essential for generating diverse diterpene hydrocarbon scaffolds. While some diTPSs also form oxygenated compounds, more commonly, oxygenation is achieved by cytochrome P450-dependent mono-oxygenases. Recent genome-, transcriptome-, and metabolome-guided gene discovery and enzyme characterization identified novel diTPS functions that form the core of complex modular pathway systems. Insights into diterpene metabolism may translate into the development of new bioengineered microbial and plant-based production systems.

Keywords
diterpene synthase; plant chemical diversity; synthetic biology; metabolic engineering; natural product biosynthesis
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Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 7, July 2015, Pages 419–428
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us