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Emerging microengineered tools for functional analysis and phenotyping of blood cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
36972 45292 2014 9 PDF Available
Title
Emerging microengineered tools for functional analysis and phenotyping of blood cells
Abstract

•Microengineered tools are capable of precise manipulation of single cells to achieve rapid, high-resolution, multiparameter functional analysis and phenotyping of blood cells.•Microfluidics enables high-throughput deformability measurements on single RBCs and WBCs, as well as easy assessment of ATP release by RBCs.•Microengineered functional immunoassays enhance the performance of traditional immunoassays and allow label-free detection of cytokines.•Microengineered tools enable easy and accurate evaluation of various platelet functions, from platelet adhesion to platelet contraction.

The available techniques for assessing blood cell functions are limited considering the various types of blood cell and their diverse functions. In the past decade, rapid advances in microengineering have enabled an array of blood cell functional measurements that are difficult or impossible to achieve using conventional bulk platforms. Such miniaturized blood cell assay platforms also provide the attractive capabilities of reducing chemical consumption, cost, and assay time, as well as exciting opportunities for device integration, automation, and assay standardization. This review summarizes these contemporary microengineered tools and discusses their promising potential for constructing accurate in vitro models and rapid clinical diagnosis using minimal amounts of whole-blood samples.

Keywords
blood cell; functional analysis; phenotyping; microengineering; microfluidics
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 11, November 2014, Pages 586–594
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us