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Engineering therapeutic proteins for cell entry: the natural approach

Paper ID Volume ID Publish Year Pages File Format Full-Text
36979 45293 2015 9 PDF Available
Title
Engineering therapeutic proteins for cell entry: the natural approach
Abstract

•Toxins and viruses provide natural templates for the design of intracellular biologics.•Endosomal entrapment is a major issue for cytoplasmic delivery.•Antibodies are effective in redirecting toxin catalytic domains for therapy.•Protein engineering can address intracellular stability and potency.

Owing to the challenges of cell entry, protein-based therapies have so far been restricted to extracellular targets, whereas intracellular targets have been almost exclusively addressed by small molecules. The specificity and potency of proteins would enable them to be effective intracellular drugs, provided that the proteins are delivered efficiently to appropriate intracellular compartments within specific cell types. By mimicking the natural mechanisms of toxins and other natural proteins, new intracellular delivery systems are being developed, the first of which are showing clinical efficacy. This review highlights a range of ingenious approaches designed to adapt natural entry mechanisms to facilitate delivery of proteins and open up a range of validated intracellular targets to modulation by potent and specific therapeutic drugs.

Keywords
intracellular; protein; toxin; virus
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 3, March 2015, Pages 163–171
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us