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Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
36989 45294 2013 5 PDF Available
Title
Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering
Abstract

•Living macrophages/monocytes can be used to enhance bone tissue engineering,•Two biomaterial-based strategies to harness macrophages/monocytes are proposed.

Bone tissue engineering has attracted considerable attention as a promising treatment modality for severe bone degeneration. The pressing need for more sophisticated and fully functional bone substitutes has spurred a refocus on the development of bone constructs in a way more comparable to the physiological process. Current research is increasingly revealing the central roles of macrophages/monocytes in regulating bone development and repair, so we propose that these immunocytes can play a similar pivotal role in directing engineered bone regeneration. Accordingly, we discuss two possible strategies to exemplify how the distinctive power of macrophages/monocytes – particularly their cytokine-secretion ability and chemotactic response to foreign materials – can be harnessed to enhance the performance of bone tissue engineering applications.

Keywords
bone tissue engineering; macrophages/monocytes; cytokine; biomaterials
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 6, June 2013, Pages 342–346
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us