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Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

Paper ID Volume ID Publish Year Pages File Format Full-Text
36993 45294 2013 9 PDF Available
Title
Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding
Abstract

•SDNs deliver targeted mutations, gene modification, and DNA insertion.•SDNs may overcome constraints within conventional and transgenic plant breeding.•Some technical and regulatory issues may challenge the commercial use of SDNs.

Conventional plant breeding exploits existing genetic variability and introduces new variability by mutagenesis. This has proven highly successful in securing food supplies for an ever-growing human population. The use of genetically modified plants is a complementary approach but all plant breeding techniques have limitations. Here, we discuss how the recent evolution of targeted mutagenesis and DNA insertion techniques based on tailor-made site-directed nucleases (SDNs) provides opportunities to overcome such limitations. Plant breeding companies are exploiting SDNs to develop a new generation of crops with new and improved traits. Nevertheless, some technical limitations as well as significant uncertainties on the regulatory status of SDNs may challenge their use for commercial plant breeding.

Keywords
site-directed nuclease; zinc-finger nucleases (ZFN); transcription activator-like effector nucleases (TALEN); meganuclease; plant breeding; genetically modified organism (GMO)
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Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 6, June 2013, Pages 375–383
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us