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Creating permissive microenvironments for stem cell transplantation into the central nervous system

Paper ID Volume ID Publish Year Pages File Format Full-Text
37001 45295 2012 9 PDF Available
Title
Creating permissive microenvironments for stem cell transplantation into the central nervous system
Abstract

Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are promising because they can repopulate lost or damaged cells and tissues. However, the adult CNS does not provide an optimal milieu for exogenous NSPCs to survive, engraft, differentiate, and integrate with host tissues. This review provides an overview of tissue engineering strategies to improve stem cell therapies by providing a defined microenvironment during transplantation. The use of biomaterials for physical support, growth factor delivery, and cellular co-transplantation are discussed. Providing the proper environment for stem cell survival and host tissue integration is crucial in realizing the full potential of these cells in CNS repair strategies.

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Creating permissive microenvironments for stem cell transplantation into the central nervous system
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 1, January 2012, Pages 55–63
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us