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Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants

Paper ID Volume ID Publish Year Pages File Format Full-Text
37005 45297 2014 5 PDF Available
Title
Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants
Abstract

•Most antioxidants show little efficacy following trauma such as TBI or stroke.•Carbon nanoparticles quench O2•−, affording no downstream radicals.•Each nontoxic nanoparticle can annihilate thousands of O2•− molecules; the same nanoparticles are selective, being inert to NO•.•Prospects are shown for the treatment of numerous O2•−-induced human pathologies.

Oxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical trials. Here we discuss the limitations of current antioxidants and describe a new class of nanoparticle antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs). PEG-HCCs show high capacity to annihilate ROS such as superoxide (O2•−) and the hydroxyl (HO•) radical, show no reactivity toward the nitric oxide radical (NO•), and can be functionalized with targeting moieties without loss of activity. Given these properties, we propose that PEG-HCCs offer an exciting new area of study for the treatment of numerous ROS-induced human pathologies.

Keywords
antioxidant; traumatic brain injury; carbon nanoparticle; oxidative stress
First Page Preview
Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 10, October 2014, Pages 501–505
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering