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Paper – a potential platform in pharmaceutical development

Paper ID Volume ID Publish Year Pages File Format Full-Text
37013 45298 2015 6 PDF Available
Title
Paper – a potential platform in pharmaceutical development
Abstract

•We revisit the process of drug discovery and the obstacles to success.•We summarize the applications of paper-based bioassays.•We examine the impact of paper-based platforms on in vitro pre-compound screening.

Paper is predominantly composed of cellulose fibers that have an inherent ability to wick fluids by capillary action; it provides an interesting diagnostic platform that is inexpensive, easily obtained, and eco-friendly. Paper has been used in various types of biologically relevant applications including paper-based molecular assays, paper-based ELISA (P-ELISA), paper-based nucleic acid assays, and paper-based cell assays. Based on recent successes with the use of paper as a platform, we contend that paper is not only very suitable for diagnostics but could provide a more advantageous platform than current plastics-based platforms for drug discovery, and would be useful for accomplishing in vitro pre-compound screening steps while offering a possible solution to several economic obstacles inherent in the pharmaceutical industry.

Keywords
bioassay; diagnostics; paper-based microfluidic device; point-of-care diagnostics; clinically based diagnostics in hospital; translational medicine
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Paper – a potential platform in pharmaceutical development
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 1, January 2015, Pages 4–9
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us