fulltext.study @t Gmail

Fc fusion as a platform technology: potential for modulating immunogenicity

Paper ID Volume ID Publish Year Pages File Format Full-Text
37016 45298 2015 8 PDF Available
Title
Fc fusion as a platform technology: potential for modulating immunogenicity
Abstract

•Fc fusion, a platform technology, is used to extend the half-life of protein drugs.•There has recently been considerable progress in understanding Fc immunobiology.•The findings suggest a rationale for engineering the Fc in fusion therapeutics.

The platform technology of fragment crystallizable (Fc) fusion, in which the Fc region of an antibody is genetically linked to an active protein drug, is among the most successful of a new generation of bioengineering strategies. Immunogenicity is a critical safety concern in the development of any protein therapeutic. While the therapeutic goal of generating Fc-fusion proteins has been to extend half-life, there is a critical mass of literature from immunology indicating that appropriate design of the Fc component has the potential to engage the immune system for product-specific outcomes. In the context of Fc-fusion therapeutics, a review of progress in understanding Fc biology suggests the prospect of engineering products that have an extended half-life and are able to modulate the immune system.

Keywords
therapeutic proteins; Fc-fusion technology; immunogenicity; neutralizing antidrug antibodies; Fc receptors; drug development
First Page Preview
Fc fusion as a platform technology: potential for modulating immunogenicity
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 33, Issue 1, January 2015, Pages 27–34
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us