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Nanoproteomics: a new sprout from emerging links between nanotechnology and proteomics

Paper ID Volume ID Publish Year Pages File Format Full-Text
37027 45299 2013 9 PDF Available
Title
Nanoproteomics: a new sprout from emerging links between nanotechnology and proteomics
Abstract

The complexity of proteomics challenges current methods to provide all peptide mass fingerprints in an ensemble measurement of various proteins at differing concentrations. To detect those low-abundance proteins, nanotechnology provides a technical platform to improve biocompatibility, specificity, reproducibility, and robustness of the current proteomic methods. Here, we comprehensively analyze the weaknesses of traditional proteomic methods and evaluate the importance of nanomaterials in significantly improving the quality of proteomic methods by manipulating individual proteins. We also illustrate how the large surface-to-volume ratio of nanomaterials can facilitate mass transfer, enhance the efficiency of separation and high-throughput capability, and reduce assay time and sample consumption. The marriage of the two subjects and the resulting new nanoproteomics will revolutionize proteomics research.

► Current proteomic techniques cannot detect all peptide fingerprints in biosamples. ► Nanotechnology has recently built a technical platform to improve biocompatibility, specificity, reproducibility, and robustness of proteomic analysis. ► Nanotechnologies convert microarrays into nanoarrays to overcome the detection limit. ► Nanomaterials can significantly improve the quality of proteomics by manipulating individual proteins.

Keywords
nanoproteomics; nanomaterials; carbon nanotubes; gold nanoparticles; nanostructured surface; nanofluidics
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Nanoproteomics: a new sprout from emerging links between nanotechnology and proteomics
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 2, February 2013, Pages 99–107
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us