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Molecular aptamers for drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
37035 45300 2011 7 PDF Available
Title
Molecular aptamers for drug delivery
Abstract

The active targeting of drugs in a cell-, tissue- or disease-specific manner represents a potentially powerful technology with widespread applications in medicine, including the treatment of cancers. Aptamers have properties such as high affinity and specificity for targets, easy chemical synthesis and modification, and rapid tissue penetration. They have become attractive molecules in diagnostics and therapeutics rivaling and, in some cases, surpassing other molecular probes, such as antibodies. In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA micelles, DNA hydrogels and carbon nanotubes.

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Molecular aptamers for drug delivery
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 12, December 2011, Pages 634–640
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering