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Artificial proteins from combinatorial approaches

Paper ID Volume ID Publish Year Pages File Format Full-Text
37040 45301 2012 9 PDF Available
Title
Artificial proteins from combinatorial approaches
Abstract

How do we create new artificial proteins? In this review, we present a range of experimental approaches based on combinatorial and directed evolution methods used to explore sequence space and recreate structured or active proteins. These approaches can help to understand constraints of natural evolution and can lead to new useful proteins. Strategies such as binary patterning or modular assembly can efficiently speed structural and functional innovation. Many natural protein architectures are symmetric or repeated and presumably have emerged by coalescence of simpler fragments. This process can be experimentally reproduced; a range of artificial proteins obtained from idealized fragments has recently been described and some of these have already found direct applications.

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Artificial proteins from combinatorial approaches
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 10, October 2012, Pages 512–520
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering